Shapiro Lab Structural Genomics

STRUCTURAL GENOMICS

The Protein Structure Initiative (PSI) is a federal, university, and industry effort aimed at dramatically reducing the costs and lessening the time it takes to determine a three-dimensional protein structure.

The long-range goal of the PSI is to make the three-dimensional atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences.

The Shapiro Lab is a participant member of the

The consortium consists five institutions in and around New York City that will develop techniques to streamline every step of structural genomics. The consortium expects to solve several hundred protein structures from humans and model organisms.

Publications

Science
2004;304:1154-1158
Disulfide-dependent multimeric assembly of resistin family hormones.
Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L
online pdf

Acta Crystallogr D Biol Crystallogr
2004;60:507-511
Structure of Escherichia coli YfdW, a type III CoA transferase.
Gogos A, Gorman J, Shapiro L
online pdf

Proteins
2003 Nov 1;53(2):320-322
Crystal structure of YdcE protein from Bacillus subtilis.
Gogos A, Mu H, Bahna F, Gomez CA, Shapiro L.
on-line pdf

Structure
2002 Dec;10(12):1669-76
Large conformational changes in the catalytic cycle of glutathione synthase.
Gogos A, Shapiro L.
on-line pdf

Structure
2000, 8:R143-R149
Screening for phasing atoms in protein crystallography.
Boggon TJ, Shapiro L
on-line pdf

Curr Opin Biotechnol
2000 Feb;11(1):31-5
Finding function through structural genomics.
Shapiro L, Harris T
on-line pdf

Science
1999 Dec 10;286(5447):2119-25
Implication of tubby proteins as transcription factors by structure-based functional analysis.
Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L
on-line pdf